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treat TB Description of Research Outputs, 2009 - 2014
Towards a world free of tuberculosis
Eur Respir J 2016; 48: 808–817 | DOI: 10.1183/13993003.00840-2016
Year one report
Ciudad de México, México - 26 al 28 de mayo del 2014
La Ceiba – Honduras, 20 - 22 de febrero, 2013 Trabajemos por prisiones y países libres de tuberculosis
Eine Stellungnahme des DZK in Zusammenarbeit mit FZB, DGI, DGPI, GPP, DGGG, DRG und DGMP Pneumologie 2016; 70: 777–780
This report investigates the impact of potential misclassification of samples on HIV prevalence estimates for 23 surveys conducted from 2010-2014. In addition to visual inspection of laboratory results, we examined how accounting for potential misclassification of HIV status through Bayesian latent ... more
This volume introduces Mongolian traditional medicine and details the nature and uses of medicinal plants found in the country. The book focuses on the medicinal plants used most commonly in Mongolia. Each monograph contains colour pictures of the plant and a wide array of information—from the sc ... more
The provision of safe and efficacious blood and blood components for transfusion or manufacturing use involves a number of processes, from the selection of blood donors and the collection, processing and testing of blood donations to the testing of patient samples, the issue of compatible blood and ... more
Consensus -based guidelines for diagnosis, prevention and treatment of tuberculosis in children and adolescents
This user guide is designed to provide national malaria control programmes with general information on glucose-6-phosphate dehydrogenase (G6PD) deficiency. Individuals with this condition may be at risk of adverse effects from medicines commonly used to cure Plasmodium vivax malaria, as well as from ... more
It is recommended that egg based quadrivalent vaccines for use in the 2019-2020 northern hemisphere influenza season contain the following: an A/Brisbane/02/2018 (H1N1)pdm09-like virus; an A(H3N2) virus to be announced on 21 March 2019*; a B/Colorado/06/2017-like virus (B/Victoria/ ... more
Как и руководство 2006 года, настоящий документ предназначен для специалистов, занимающихся разработкой государственных программ по борьбе с туберкулезом, педиатр ... more
Проект ВИЧ/ТБ инициативной группы TAG призван способствовать повышению качества исследований, программ и рекомендаций для людей, живущих с ВИЧ и туберкулезом (ТБ).

Natural History of HIV Infection

Dr. F. Amond KZN Provincial ARV; Training NRM School of Medicine; University of Kwa-Zulu Natal (2019) C2
Accessed: 03.09.2019
Брошюра состоит из двух частей. В первой приводятся практические примеры, иллюстрирующие все составляющие ухода за пациентами, во второй части представлены данны ... more
Исследование этого года основано на предыдущем отчете. В нем отслеживается утверждение последних стратегий, руководств и методов в пяти сферах: диагностика и иссл ... more

Novel point-of-care tools for early infant diagnosis of HIV

World Health Organization (2017) C_WHO
HIV Diagnostics Information Note WHO/HIV/2017.16
PQDx 0033-013-00 WHO PQ Public Report July/2016, version 5.0
PQDx 0018-010-00 WHO PQDx PR July/2016, version 3.0
PQDx 0181-031-00 WHO PQ Public Report March/2017, version 3.0
8th IAS Conference on HIV Pathogenesis 19-22 July 2015 Vancouver Anita Sands Prequalification Team – Diagnostics Essential Medicines and Health Product
UNAIDS 2017 | Explainer

Meeting Report ECDC/WHO Joint Meeting on European HIV/AIDS Surveillance 10-11 March 2016, Bratislava

ECDC European Center for disease prevention and control; World Health Organization (Europe); EACS European AIDS Clinical Society (2019) C2
Accessed: 20.11.2019
The purpose of this document is to provide interim guidance to laboratories and stakeholders involved in laboratory testing of patients who meet the definition of suspected case of pneumonia associated with a novel coronavirus identified in Wuhan, China. 19 March 2020
Eaton JW et al. Journal of the International AIDS Society 2019, 22(S1):e25237 http://onlinelibrary.wiley.com/doi/10.1002/jia2.25237/full | https://doi.org/10.1002/jia2.25237
Timely detection of novel coronavirus (2019-nCoV) infection cases is crucial to interrupt the spread of this virus. We assessed the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries. Thirty- ... more
Antimicrobials are used in veterinary medicine to treat infectious diseases in animals caused or complicated by microorganisms, mainly bacteria, or to prevent the development or spread of infection in healthy animals.
Временное руководство 19 марта 2020 г. Данный документ предоставляет временное руководство лабораториям и заинтересованным сторонам, участвующим в лабораторном ... more
Epidemiologische Lage Grundsätze für die Hausärztliche Praxis Organisatorische Hinweise Mögliche Optionen zur Entlastung der Praxis Klinische Hinweise zur Behandlung von Covid-19-Fällen Weitere Informationen
Accessed: 02.04.2020
Scientific Brief 9 July 2020
Interium guidance, 25 June 2021Timely and accurate diagnostic testing is an essential tool in preventing and controlling the spread of COVID-19. This document describes recommendations for national testing strategies and the use of PCR and rapid antigen tests in different transmission scenarios of t ... more
The speed of developing diagnostics for SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), has been quite remarkable. Diagnostics have focused on nucleic acid amplification testing (NAAT) to identify infected individuals in acute-phase disease for timely implementation of mitiga ... more
In this document, recommendations are provided on designing and implementing a cross-sectional serosurvey using school-based sampling to estimate age-specific DENV seroprevalence to inform a country’s national dengue vaccination program. The document includes recommendations for methods for ... more
Available in Arabic, Chinese, English, French, Portuguese and Spanish https://apps.who.int/iris/handle/10665/334254
Interim guidance, 6 October 2021 Direct detection of SARS-CoV-2 viral proteins (antigens) in nasal swabs and other respiratory secretions using lateral flow immunoassays (also known as rapid diagnostic tests, RDTs) offers a faster and less expensive method to test for SARS-CoV-2 than the reference ... more
The purpose of this document is to provide guidance on the use of pooled sample testing strategy in coronavirus disease (COVID-19) testing laboratories of the African Union Member States for scaling up SARS-CoV-2 nucleic acid testing capacity with the available resources. The current document descr ... more
This document provides interim guidance on the prevention, identification and management of health worker infection in the context of COVID-19. It is intended for occupational health departments, infection prevention and control departments or focal points, health facility administrators and public ... more
5 Nov. 2020 The policy brief provides a concise summary of information and considerations to ensure optimal management of influenza during the COVID-19 pandemic. It includes a list of technical guidance and other resources to assist policy makers with monitoring the situation, preventing seasonal i ... more
Epidemiologisches Bulletin3 | 202121. Januar 2021 (online vorab)
16 Dec. 2020 This document provides guidance to Ministries of Health (MOHs), laboratory personnel and implementing partners in African Union Member States on the application of rapid antigen tests to COVID-19 testing. The guidance serves as reference for policymakers, laboratory leads, implementing ... more
Available in English, French, Spanish, Chinese, Russian and Arabic https://apps.who.int/iris/handle/10665/337832
8 January 2021 Sequencing enabled the world to rapidly identify SARS-CoV-2 and develop diagnostic tests and other tools for outbreak management. Continued genome sequencing supports the monitoring of the disease’s spread and evolution of the virus. Accelerated integration of genome sequencing int ... more
The growing understanding of how sequence information can contribute to improved public health is driving global investments in sequencing facilities and programmes. The falling cost and complexity of generating GSD provides opportunities for expanding sequencing capacity; however, challenges to wid ... more
The WHO COVID-19 LENS (Living Evidence Synthesis) working group consolidated available evidence, based on rapid reviews of the literature and results of a living systematic review on pregnancy and COVID-19 (up to October 7, 2020), on potential mechanisms of vertical transmission of infectious pathog ... more
29 Dec 2021. Comprehensive slideset updated regularly to include the latest data and guidance on best practices for COVID-19 diagnosis and prevention of COVID-19 transmission.
In 2019, an estimated 10 million individuals fell ill with tuberculosis (TB) and 3 million of them were not reported to have beendiagnosed and notified. The gap is proportionately even wider for drug-resistant TB. Of the estimated 465 000 patients with rifampicin-resistant and multi-drug resistant T ... more
6 July 2021. The “WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection 2021 update” is the latest document replacing the one issued in 2020. Three new nucleic acid amplification test (NAAT) classes are endorsed by WHO and included in the ... more
Countries across the world are facing diverse epidemiological situations with varying response capacities and access to life saving tools. The World Health Organization (WHO) recommends that national authorities continue to apply a risk-based approach when implementing measures related to COVID-19 ... more
OBJETIVO DE LA GUÍA Describir los lineamientos técnicos de la vigilancia de tuberculosis por el laboratorio, así como los procesos de obtención, recolección, procesamiento, transporte y conservación de muestras, y las funciones que se realizan y articulan por todos los integra ... more
This document aims to describe a minimum set of surveillance activities recommended at the national level to detect and monitor the relative prevalence of SARS-CoV-2 variants and outline a set of activities for the characterization and assessment of risk posed by these variants. A set of indicators ... more
21 January 2022 The overall threat posed by Omicron largely depends on four key questions: (i) how transmissible the variant is; (ii) how well vaccines and prior infection protect against infection, transmission, clinical disease and death; (iii) how virulent the variant is compared to other varian ... more
This policy guideIine is intended for use by healthcare professionals invoIved in the management of Covid-19 in South Africa. The document provides guidance on diagnostic tests available, on antigen test performance and accessibility. 1t focuses on key issues such as when to Perform antigen tests ... more
9 March 2022, Timely and accurate diagnostic testing for SARS-CoV-2 is an essential part of a comprehensive COVID-19 response strategy. Ag-RDTs can be performed by individuals in which they collect their own specimen, perform a simple rapid test and interpret their test result themselves at a time a ... more
Despite the human and economic impact of viral epidemics, the world is not well enough prepared for the next emerging viral outbreak. Global trends indicate that new microbial threats will continue to emerge at an accelerating rate, driven by our growing population, expanded travel and trade network ... more
Any individual that meets the suspected case definition of monkeypox should be offered testing in appropriately equipped laboratories by staff trained in the relevant technical and safety procedures. Confirmation of monkeypox virus infection is based on nucleic acid amplification testing (NAAT), usi ... more
The World Health Organization (WHO) recognizes the challenges countries face for maintaining their COVID-19 response while addressing competing public health challenges, conflicts, climate change and economic crises. It remains critical for national programmes to continue to offer testing for COVI ... more
The World Health Organization Global TB Report provides a comprehensive and up-to-date assessment of the TB epidemic, and progress in the response, at global, regional and country levels. The 2022 edition features data on disease trends and the response to the epidemic from 215 countries and area ... more
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are ... more
• Leptospirosis is a disease that is caused by spirochete bacteria in the genus Leptospira. There are 10 pathogenic species, and more than 250 pathogenic serovars. • While leptospirosis occurs worldwide, it is more common in tropical or sub-tropical climates.
Rabies has an enormous impact on both agriculture and conservation biology, but its greatest burden is undeniably on public health. As such, routine methods for rapid risk assessment after human exposures to rabies as well as applications for laboratory-based surveillance, production of biologicals ... more
BMJ Open 2021;11:e042279. doi:10.1136/bmjopen-2020-042279. Neglected tropical diseases tend to cluster in the same poor populations, and to make progress with their control, they will have to be dealt with in an integrated manner. Peptide microarrays may be a solution to tese problems, where diagnos ... more
Human African trypanosomiasis (HAT), or sleeping sickness, is an endemic disease in 36 sub-Saharan African countries, typically occurring in underdeveloped areas, where health systems face significant difficulties of diverse natures.
This WHO laboratory manual provides the most up to date methods and procedures for the laboratory identification of yellow fever virus infection in humans. It provides guidance on the establishment and maintenance of an effective laboratory providing routine surveillance testing for yellow fever, wh ... more
Protection from a Single Dose of HPV Vaccine A major public health impact from IARC studies of vaccine efficacy.

A 20-year follow-up study on chronic respiratory effects of exposure to cotton dust

Wang, X-R.; Zhang, H-X.; Sun, B-X.; et al. European Respiratory Journal, part of the European Respiratory Society (ERS) (2005) CC2
The article "A 20-year follow-up study on chronic respiratory effects of exposure to cotton dust" evaluates the long-term impact of cotton dust exposure on respiratory health. It followed a cohort of Chinese cotton and silk workers from 1981 to 2001, comparing lung function and symptoms. Results sho ... more
HIV testing programmes need to ensure that all clients who test for HIV are provided with correct diagnoses. The accuracy of HIV testing is critical to prevent misdiagnosis, as the consequences of giving an incorrect test result can be serious for clients, HIV testing services, HIV programmes and pu ... more
The module is currently available in English, French, Nepali, Portuguese, Russian, and Spanish
This Tuberculosis guide has been developed jointly by Médecins Sans Frontières and Partners In Health. It aims at providing useful information to the clinicians and health staff for the comprehensive management of tuberculosis. Forms of susceptible and resistant tuberculosis, tuberculosis in child ... more
• provide scientific information on the safety, efficacy, and quality control/ quality assurance of widely used medicinal plants, in order to facilitate their appropriate use in Member States; • provide models to assist Member States in developing their own mono- graphs or formularies for these ... more
• provide scientific information on the safety, efficacy, and quality control/ quality assurance of widely used medicinal plants, in order to facilitate their appropriate use in Member States; • provide models to assist Member States in developing their own mono- graphs or formularies for these ... more
• provide scientific information on the safety, efficacy, and quality control/ quality assurance of widely used medicinal plants, in order to facilitate their appropriate use in Member States; • provide models to assist Member States in developing their own mono- graphs or formularies for these ... more
HIV & AIDS Treatment in Practice No. 198
HIV & AIDS Treatment in Practice No. 188
The 7th edition of the Orange Guide provides practical guidance to health workers on the front line of TB control. It includes sections on HIV, MDR-TB and a review of the recommended treatment regimens
4th edition. This is fourth edition of Treatment of tuberculosis: guidelines, adhering fully to the new WHO process for evidence-based guidelines. Several important recommendations are being promoted in this new edition
Biology, Diagnosis and Treatment, Epidemiology and Prevention
Handbook of Foodborne Pathogenic Microorganisms and Natural Toxins
2nd edition. These guidelines provide guidance on the diagnosis of human immunodeficiency virus (HIV) infection, the use of antiretroviral (ARV) drugs for treating and preventing HIV infection and the care of people living with HIV. They are structured along the continuum of HIV testing, prevention, ... more
Improve identification, verification, communication and coordination.

District Laboratory Practice in Tropical Countries Part-2

Cheesbrough, M. Cambridge University Press (2006) C4
Exciting new treatment approaches make the management of hepatitic C one of the most rapidly developing areas of medicine. The Flying Publisher short Guide to Hepatitis C is an up-to-date source of information for physicians, residents and advanced medical students.
Guidance for health workers
Clinical management handbook
This position paper on polio vaccines replaces the 2016 WHO position paper, and summarizes recent developments in the field.