Interim Assessement Report
The EMA review was started by the Agency’s Committee for Medicinal Products for Human Use (CHMP) to support decision-making by health authorities. This first interim report includes information on seven experimental medicines intended for the treatment of people infecte...d with the Ebola virus:
BCX4430 (Biocryst);
Brincidofovir (Chimerix);
Favipiravir (Fujifilm Corporation/Toyama);
TKM-100802 (Tekmira);
AVI-7537 (Sarepta);
ZMapp (Leafbio Inc.);
Anti-Ebola F(ab’)2 (Fab’entech).
The amount of information available for the seven treatments is highly variable. For some compounds there is no data from use in human subjects available. A small number of treatments have been administered to patients in the current Ebola outbreak as compassionate use. Finally, there are also medicines included in this review that have already been studied in humans, albeit for the treatment of other viral diseases.
more
A review of current literature and up date data from the field, April 2015.
This report has been published in part in J Hosp Inf. 2015;90:1-9.
http://www.ncbi.nlm.nih.gov/pubmed/?term=ebola+nosocomial+shears
The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.
PLoS Negl Trop Dis 11(2): e0005356 -Published: February 23, 2017 21 pp
Emergency WASH in Health Facilities in Conflict Affected Locations 756 health workers trained on disease surveillance and outbreak response.
Around 142 health workers trained on integrated health (WASH and Nutrition) response. 405 health facilities are equipped with functional incinerators.
Qual...ity Essential Clinical Health Services 194 health workers are trained on clinical management of rape (CMR) in 2018. 259 sexual and gender based violence (SGBV) survivors referred to the health facilities.
Improving Resilience- Mental Health Response 514 health workers trained on mental health and psychosocial support (MPHSS) in conflict affected areas.
more
The purpose of this pocketbook is to provide clear guidance on current best management practices for VHF across health-care facilities
Cette liste de contrôle devrait aider les pays à évaluer et à tester leur niveau de préparation pour faire face à la propagation de maladie à virus Ebola. Elle doit également servir d'outil pour identifier des actions concrètes à prendre et les moyens pour la communauté internationale de ...les appuyer pour combler les lacunes potentiellement existantes.
more
Infectious Diseases of Poverty 2014, 3:42
http://www.idpjournal.com/content/3/1/42
mBio, Vol. 6 Issue 2, March/April 2015
Available evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. In this review, the authors address what we know and what ...we do not know about Ebola virus transmission. They also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
more
Trop Med Int Health. 2015 Apr; 20(4): 448–454. Open Access
Up-to-date Literature review current through: Jan 2015. | This topic last updated: Jan 29, 2015.
Interim emergency guidelines
Provisional recommendations May 2014
Cette liste de contrôle devrait aider les pays à évaluer et à tester leur niveau de préparation pour faire face à la propagation de maladie à virus Ebola. Elle doit également servir d'outil pour identifier des actions concrètes à prendre et les moyens pour la communauté internationale de ...les appuyer pour combler les lacunes potentiellement existantes.
Elle recense 10 composantes et tâches essentielles à mettre en oeuvre à la fois par les pays et la communauté internationale dans les 30, 60 et 90 jours respectivement suivant sa date de publication. Les exigences minimales en termes d'équipements et de matériel ainsi que les ressources humaines nécessaires sont définies.
more
The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub...lic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.
more