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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Overview of capacity building opportunities in “One Health”, internationally and with focus on Africa

Deutsche Gesellschaft für Internationale Zusammenarbeit GIZ (2022) CC2

An interdisciplinary approach to address global health challenges such as the Covid-19 pandemic, climate change, loss of biodiversity, human migration has been framed by the One Health approach. This approach is promoted at global level by the Tripartite of the World Health Organisation, the World A... more

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Increasing Community Disaster Awareness

IFRC - International Federation of Red Cross Red Cresent Societies (2000) CC

Disaster Preparedness Training Programme

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Integrated Management of Neonatal and Childhood Illness - Facilitator Guide I

Ministry of Health and Family Welfare, Government of India; WHO; UNICEF (2009) C_WHO

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DRC: Adolescent contraceptive use

World Health Organization (WHO) (2016) C_WHO

Data from l'Enquête Démographique et de Santé (EDS-RDC) en République Démocratique du Congo, 2013-14

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Syllabus on diploma in community based rehabilitation (D-CBR) - India

Rehabilitation Council of India, Ministry of Social Justice and Empowerment (2007) C2

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Green Climate Fund Proposal Toolkit 2017: Toolkit to develop a project proposal for the GCF

Fayolle, Virginie; Odianose, Serena Acclimatise, Climate and Development Knowledge Network (CDKN) (2017) C1

The GCF aims to support developing countries in achieving a paradigm shift to low-emission and climate-resilient pathways. This is achieved by funding innovative and transformative lowemission (mitigation) and climate-resilient (adaptation) projects and programmes developed by the public and private... more

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Central African Republic: National Recovery and Peacebuilding Plan 2017-21

World bank group The World Bank (2017) CC

The Central African Republic is at a major turning point in its history. The country is just emerging from a very violent conflict, during which thousands of human lives were lost and one-third of the population was displaced. After a three-year transition, and with the support of the internationa... more

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National consolidated Guidelines for comprehensive HIV prevention, care and treatment

World Health Organization (Africa) (2018) C_WHO

“Continuum of HIV services refers to a comprehensive package of HIV prevention, diagnostic, treatment, care and support services provided for people at risk of HIV infection or living with HIV and their families” August, 2018

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CAWST Soap Making Fact Sheet

Center for Affordable Water and Sanitation Technology CAWST (2014) CC

This fact sheet developed by CAWST describes the history of soap, how it’s made, and the two processes for making soap. This fact sheet is available in English, Spanish, and French.

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Fiche technique sur le savon : Fabrication du savon

Center for Affordable Water and Sanitation Technology CAWST (2014) CC

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Hoja informativa sobre el jabón: Fabricación de jabón

Center for Affordable Water and Sanitation Technology CAWST (2014) CC

National Implementation Guidelines for HIV and STI Programming Among Young Key Populations

NASCOP (National AIDS & STI Control Programme), Kenya (2018) CC

These guidelines were developed as part of Kenya's fast-track plan to end AIDS among adolescents and young people. Based on research into adolescent and young key populations in Kenya and elsewhere, they outline a package of HIV prevention services, and emphasize the need to combine biobehavioural i... more

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WHO Guideline on use of ferritin concentrations to assess iron status in individuals and populations

World Health Organization WHO (2020) C_WHO

This guideline provides global, evidence-informed recommendations on the use of indicators for assessing a population’s iron status and application of the use of ferritin concentrations for monitoring and evaluating iron interventions.

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The Practical Approach to Care Kit (PACK) guide: developing a clinical decision support tool to simplify, standardise and strengthen primary health care delivery

Cornick, Picken, Wattrus et al. BMJ Global Health Journal (2018) CC

For the primary health worker in a low/middle-income country (LMIC) setting, delivering quality primary care is challenging. This is often complicated by clinical guidance that is out of date, inconsistent and informed by evidence from high-income countries that ignores LMIC resource constraints and... more

What are patient navigators and how can they improve integration of care?

Budde, H.; G.A.Williams, G. Scarpetti, et al. World Health Organization WHO, Regional Office of Europe (2021) C_WHO

Policy brief

Managing epidemics: key facts about major deadly diseases

World Health Organization (WHO) (2018) C_WHO

Epidemics of infectious diseases are occurring more often, and spreading faster and further than ever, in many different regions of the world. The background factors of this threat are biological, environmental and lifestyle changes, among others. A potentially fatal combination of newly-discovered ... more

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Strengthening Nutrition Information Systems in Cote d'Ivoire, Ethiopia, Lao People's Democratic Republic, Uganda and Zambia (EC-NIS Project)

World Health Organization WHO, Regional Office of Africa (2022) C_WHO

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Joint Operational Framework Health and Protection

Protection Cluster; UN High Commissioner for Refugees (2023) C1

Each humanitarian setting provides distinct opportunities and challenges for actors to coordinate and collaborate at strategic and operational levels. The Health and Protection Joint Operational Framework has been developed to ensure that the health and protection response during humanitarian emerge... more

Capacity building in public health nutrition

Geissler, C. Proceedings of the Nutrition Society (2015) CC

The aim of the present paper is to review capacity building in public health nutrition (PHN), the need for which has been stressed for many years by a range of academics, national and international organisations. Although great strides have been made worldwide in the science of nutrition, there rema... more