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Publication Years
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Human African trypanosomiasis (HAT), or sleeping sickness, is a painful and protracted disease transmitted through the bite of infected tsetse flies and it is found in rural parts of sub-Saharan Africa. Sleeping sickness has two clinical phases but
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this review focuses only on treatment of the second-stage, which is characterized by neurological changes and almost invariably fatal without treatment. There are only a few drugs currently available for second-stage sleeping sickness, all with considerable adverse events and variable efficacy.
The review includes nine trials with 2577 participants. Each trial reported different comparisons of the drugs currently available to treat second stage HAT (melarsoprol, eflornithine, nifurtimox) so no meta-analysis was possible.
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Schistosomiasis is a chronic disease linked to poverty and is widely endemic, particularly in sub-Saharan Africa. For decades, the World Health Organization has called for a larger role of the primary health care system in schistosomiasis control, a
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nd its integration within the routine activities of primary health care facilities. Here, we reviewed existing studies on the integration of schistosomiasis control measures within the primary health care system, more precisely at the health centre, and we analysed their outcomes.
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South Africa’s mineral resources have produced, and continue to produce, enormous economic wealth; yet decades of colonialism, apartheid, capital flight, and challenges in the neoliberal post-apartheid era have resulted in high rates of occupation
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al lung disease and low rates of compensation for ex-miners and their families. Given growing advocacy and activism of current and former mine workers, initiatives were launched by the South African government in 2012 to begin to address the legacy of injustice. This study aimed to assess developments over the last 5 years in providing compensation, quantify shortfalls and explore underlying challenges.
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Gambiense human African trypanosomiasis is a deadly infectious disease affecting West and Central Africa, South Sudan and Uganda, and transmitted between humans by tsetse flies. The disease has caused several major epidemics, the latest one in the 1
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990s. Thanks to recent innovations such as rapid diagnostic tests for population screening, a single-dose oral treatment and a highly efficient vector control strategy, interruption of transmission of the causative parasite is now within reach. If indeed gHAT has an exclusively human reservoir, this could even result in eradication of the disease. Even if there were an animal reservoir, on the basis of epidemiological data, it plays a limited role. Maintaining adequate postelimination surveillance in known historic foci, using the newly developed tools, should be sufficient to prevent any future resurgence.
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Community feedback considered in this report was collected through information received from Community Engagement and Accountability (CEA) focal points,as well as through primary data collection,in 10 African countries.Red Cross and Red Crescent National Society CEA focal points were asked to share
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the main rumours, observation, beliefs, questions or suggestions they are hearing in their countries andto grade them according to their frequency. Focal points from the following countries provided information this way: Botswana, Burundi, Cameroon, Niger, South Africa.
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As informações comunitárias consideradas no presente relatório foram obtidas através dos dados fornecidos pelos pontos focais de participação e responsabilização comunitárias (Community Engagement and Accountability–CEA), bem como através da recolha de dados primários, em dezpaíses af
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ricanos.Os pontos focais de CEA das Sociedades Nacionais da Cruz Vermelha e do Crescente Vermelho foram convidados a partilhar os principais rumores, comentários, crenças, perguntas ou sugestões registados nos seus países e a classificá-los em função da respetiva frequência. Os pontos focais dos países enumerados abaixo forneceram informações desta forma: Botsuana, Burundi, Camarões, Níger, África do Sul.
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New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
Dickie, E.A.; Giordani, F.; Gould, M.K.; Mäser, P.; Burri, C.; Mottram, J.C.; Rao, S.P.S.; Barrett, M.P.
MDPI Tropical Medicine and Infectious Disease
(2020)
CC2
The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous succes
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s against HAT and the competing priorities associated with other medical crises ravaging the continent. A series of dedicated interventions and the introduction of innovative routes to develop drugs, involving Product Development Partnerships, has led to a dramatic turnaround in the fight against HAT caused by Trypanosoma brucei gambiense. The World Health Organization have been able to optimize the use of existing tools to monitor and intervene in the disease. A promising new oral medication for stage 1 HAT, pafuramidine maleate, ultimately failed due to unforeseen toxicity issues. However, the clinical trials for this compound demonstrated the possibility of conducting such trials in the resource-poor settings of rural Africa.
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The epidemiology of the disease is mediated by the interaction of the parasite (trypanosome) with the vectors (tsetse flies), as well as with the human and animal hosts within a particular environment. Related to these interactions, the disease is confined in spatially limited areas called “foci
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, which are located
in Sub-Saharan Africa, mainly in remote rural areas. The risk of contracting HAT is, therefore, determined by the possibility of contact of a human being with an infected tsetse fly. Epidemics of HAT were described at the beginning of the 20th century; intensive activities have been set up to confront the disease, and it was under control in the 1960s, with fewer than 5,000 cases reported in the whole continent.
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This regional advocacy strategy on HIV and AIDS, tuberculosis (TB) and sexually transmitted infetions (STIs) is intended for use by Southern African Development Community (SADC) Member States at a national level. This is an overall advocacy strategy
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highlighting the most important issues relating to HIV and AIDS, TB and STIs in the Southern African region. It provides a broad advocacy framework for each of the issues identied, along with key targets, messages, and interventions
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EL Nino events are associated with the warming of the Sea Surface Temperatures (SST) over the tropical Pacific Ocean, which significantly influences rainfall in various parts of the world. Recent El Nino events occurred in 1982/83, 1987/88, 1991/92, 1997/98, 2002/03, 2004/05, 2006/07, 2009/10 and 20
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15/16 but at varying strength.
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Coronavirus disease 2019 (COVID-19) Quick Reference for Health Workers Case
Centre for Respiratory Diseases and Meningitis, South Africa
National Institute for Communicable Diseases (NICD)
(2020)
C2
On the 31st December 2019, the World Health Organization (WHO) China country office reported a cluster of pneumonia cases in Wuhan City, Hubei Province of China now known to be caused by a novel virus. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been confirmed as the causative v
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irus of Coronavirus disease 2019 (COVID-19). Cases have now been identified in over 100 countries including South Africa.
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Guideline: Adherence to antiretroviral therapy in adolescents and young adults (expanded version)
L. Fairlie; L. Jankelowitz; H. Ronald; et al.
Southern African HIV Clinicians Society; Right to Care (Training Health Seriously)
(2017)
C2
Recommendations, resources and references
A publication of the Southern African HIV Clinicians Society
Quick reference guide
High Transmission Areas: Key Populations
May 2022
Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren
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dering them ineffective and making infections more difficult to treat. This resistance increases the risk of disease spread, severe illness, disability, and death. Although AMR is a natural phenomenon driven by genetic
changes in pathogens, it is significantly accelerated by human activities such as the misuse and overuse of antimicrobials in healthcare, agriculture, and animal husbandry.
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