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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Tuberculosis advocacy communication & social mobilization

S. Sengupta, W. Nkhoma, O. Walker, et al. World Health Organization (2017) C_WHO

This paper looks at the status of tuberculosis (TB) advocacy communication and social mobilization (ACSM) activities in selected national TB control programmes in the WHO African Region. The findings are from an assessment of TB ACSM activities in Ghana, Kenya, Lesotho, Malawi and South Africa. ... more

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Working with persons with disabilities in forced displacement

UN High Commissioner for Refugees (2011) C1

Refugees1 with disabilities have specific needs and face particular forms of discrimination. As highlighted in the Executive Committee Conclusion No. 110 (LXI)–2010, it is important for UNHCR to ensure that the rights of persons with disabilities who are of concern to the Office are met without di... more

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Global Vaccine Summit 2020 - Chair’s Summary

Global Alliance for Vaccines and Immunisation (Gavi) Global Alliance for Vaccines and Immunisation (Gavi) (2020) CC

The UK government hosted the Global Vaccine Summit on June 4, 2020 under the patronage of the Rt. Hon. Boris Johnson, Prime Minister of the United Kingdom of Great Britain and Northern Ireland. The meeting was held by videoconference in light of the ongoing COVID-19 pandemic. 2. The Summit brought... more

2020 Heart Failure Society of South Africa perspective on the 2016 European Society of Cardiology Chronic Heart Failure Guidelines

Hitzeroth, J.; Mpe, M.; Klug, E. et al. The South African Medical Journal (2020) CC

Heart failure with a reduced ejection fraction (HFrEF) is a condition frequently encountered by healthcare professionals and, in order to achieve the best outcomes for patients, needs to be managed optimally. This guideline document is based on the European Society of Cardiology Guidelines for the t... more

Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection (March 2024)

World Health Organization WHO (2024) C_WHO

Hepatitis B (HBV) infection is a major public health problem and cause of chronic liver disease. The 2024 HBV guidelines provide updated evidence-informed recommendations on key priority topics. These include expanded and simplified treatment criteria for adults but now also for adolescents; expa... more

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Biodiversity & Infectious Diseases - Questions & Answers

Convention on Biological Diversity (2020) C2

Infectious diseases cause over one billion human infections per year, with millions of deaths each year globally. Extensive health and financial burden is seen from both established and emerging infectious diseases. Infectious diseases also affect plants and animals, which may pose threats to agricu... more

Atlas of African Health Statistics 2022: Health situation analysis of the WHO African Region

World Health Organisation (WHO) (2022) C_WHO

Atlas of African Health Statistics 2022: Health situation analysis of the WHO African Region Since 2019, we have been implementing Phase 2 of the regional Transformation Agenda, which informs and aligns with the global WHO Transformation, to ensure WHO is accountable, driven by re- sults and provid... more

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The World Medcines situation 2011 Rational use of Medicines

World Health Organization WHO (2011) C_WHO

Millennium Development Goal 8E aims for affordable access to essential medicines. Essential medicines, as defined by WHO, are those that “satisfy the health-care needs of the majority of the population” and that should therefore “be available at all times in adequate amounts”. However, there... more

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Reproductive Health Assessment Toolkit for Conflict-Affected Women (Cover)

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Department of Health and Human Services, (2007)

This is only the cover of the book. Download the whole Toolkit at: www.cdc.gov/reproductivehealth/Refugee/ Understanding the reproductive health needs of conflict-affected women will enable organizations to implement and enhance programs and services to improve the health of women and their fam... more

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Prevention and Recognition of Obstetric Fistula Training Package. Participant Handbook

EngenderHealth; Fistula Care; USAID (2012) CC

Fistula Care's implementing partner in Ethiopia, IntraHealth, has developed materials to train health workers on obstetric fistula prevention, identification, and pre-repair care. The course contains a participant handbook (PDF, 604 KB), a facilitator manual (PDF, 1.3 MB), ten modules, a variety of ... more

Water, sanitation and hygiene in health care facilities: status in low and middle income countries and way forward.

Maria Neira, Edward Kelley, Mickey Chopra et al. World Health Organization, UNICEF (2015)

This report presents, for the first time, a global assessment of the extent to which health care facilities provide essential water, sanitation and hygiene (WASH) services. Drawing on data from 54 low- and middle-income countries, the report concludes that 38% lack access to even rudimentary levels ... more

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The Essential Health service Package for Botswana

Ministry of Health, Gabarone, Botswana; PEPFAR; CDC (2010) C2

The EHSP in Botswana seeks to attain universal coverage of high-quality package of essential health services. The EHSP is an integrated collection of cost-effective interventions, promotive, preventive, curative, and rehabilitative, that address the main diseases, injuries and risk factors that affe... more

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Rwanda: Non COMMUNICABLE DISEASES Policy

Ministry of Health, Rwanda (2015) C2

This document outlines Rwanda's policy on non-communicable diseases. The overall goal of NCDs Policy is to alleviate the burden of NCDs and their risk factors and protect Rwandan population from premature morbidity and mortality related to NCDs. This policy was developed through a series of consulta... more

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Using Performance Incentives to Improve Health Outcomes

Gertler, P. & Vermeersch, C. The World Bank (2012) C2

Policy Research Working Paper 6100 | Impact Evaluation Series No. 60 | This study examines the effect of performance incentives for health care providers to provide more and higher quality care in Rwanda on child health outcomes. The authors find that the incentives had a large and significant effec... more

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Paying Primary Health Care Centers for Performance in Rwanda

Basinga, P., Gertler, P.J., Binagwaho, A., et al. The World Bank (2010) C2

Paying for performance (P4P) provides financial incentives for providers to increase the use and quality of care. P4P can affect health care by providing incentives for providers to put more effort into specific activities, and by increasing the amount of resources available to finance the delivery ... more

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Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies

Alipanah N, Jarlsberg L et al. (2018) CC

We systematically reviewed Medline as well as the references of published review articles for relevant studies of adherence to multidrug treatment of both drug-susceptible and drug-resistant TB through February 3, 2018. We included randomized controlled trials (RCTs) as well as prospective and retro... more

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Papua New Guinea: Disaster Management Reference Handbook

Center for Excellence in Disaster Management and Humanitarian Assistance (2016) C1

The 2012 NDRMP lays out the Disaster Risk Management (DRM) architecture of the country and provides guidance for DRM intervention at all levels. However, implementation has been slow and resource challenges exist throughout the government.
The PNG government’s policy and institutional framework... more

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Mycobacterium tuberculosis resistance to antituberculosis drugs in Mozambique

Germano MP, Elena F, Ndlovu N et al (2013) CC

This study aimed to determine the drug resistance profile of Mycobacterium tuberculosis in Mozambique and concludes that M. tuberculosis resistance to antituberculosis drugs is high in Mozambique, especially in previously treated patients. The frequency of M. tuberculosis strains that were resistant... more

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Gesundheit - (K)ein Menschenrecht? - Ein Arbeitsheft zum Thema "Gesundheit weltweit" für Lehrende und Lernende

Deutsche Lepra- und Tuberkulosehilfe (2018)

Liebe Lehrende, das Recht auf Gesundheit ist ein weltweites Menschenrecht. Dennoch gestalten sich die vielen ge-sundheitlichen Facetten in jedem Land der Erde ganz unterschiedlich. So kann dieses Menschen-recht in vielen Ländern leider oftmals nicht vollständig oder sogar überhaupt nicht eingeha... more