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Q&A: Antibiotic resistance: where does it come from and what can we do about it?

Wright G.D. BMC Biology (2010) C2

Historically, the discovery of the sulfa drugs in the 1930s and the subsequent development of penicillin during World War II ushered in a new era in the treatment of infectious diseases. Infections that were common causes of death and disease in the pre-... more

Infection Control and Waste Management Plan (ICWMP) for Kenya COVID-19 Emergency Response Project

Ministry of Health, Kenya (2020) CC

COVID-19 outbreak is associated with the generation of many types of infectious wastes, including infected masks, gloves and other protective equipment, together with a higher volume of general waste of the same nature.

Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Estimating COVID-19 vaccine effectiveness against severe acute respiratory infections (SARI) hospitalisations associated with laboratory-confirmed SARS-CoV-2

World Health Organization WHO (2021) C_WHO

Many critical questions remain about the effectiveness of COVID-19 vaccines in real-world settings. These questions can only be answered in post-introduction vaccine effectiveness studies.This guidance document outlines an approach to leverage existing surveillance systems for Severe Acute Respirato... more

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How to Obtain a Nasopharyngeal Swab Specimen

Marty, F.M.; et al. New England Journal of Medicine (2020) CC

New England Journal of Medicne NJM 2020 382, 22 You can download the video here https://medbox.org/document/how-to-obtain-a-nasopharyngeal-swab-specimen-video#GO

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Integrated Management of Childhood Illness (IMCI) - 2019 (Updated)

National Department of Health South Africa National Department of Health South Africa (2019) CC

Integrated Management of Childhood Illness (IMCI) is an integrated approach to child health that focuses on the holistic well-being of the child. IMCI aims to reduce death, illness and disability, and to promote improved growth and development among children under five years of age. IMCI includes bo... more

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Eradication of yaws: a guide for programme managers, a disfiguring non-venereal disease

World Health Organization WHO (2018) C_WHO

Yaws is a disfiguring non-venereal disease caused by infection with the spirochaete. Treponema pallidum subspecies pertenue which is closely related to the causative agent of syphilis and those of the other endemic treponematoses, bejel and pinta. The disease is endemic in certain areas of the World... more

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Ghana: Public Health Act

Government of Ghana (2012) C1

Act 851 | AN ACT to revise and consolidate the law relating to public health to prevent disease, promote, safeguard, maintain and protect the health of humans and animals and to provide for related matters.

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Rwanda: MOH GUIDELINES ON SUBMISSION OF DOCUMENTATION FOR REGISTRATION OF HUMAN PHARMACEUTICAL PRODUCTS

Ministry of Health, Rwanda (2014) C2

These guidelines have been developed to provide guidance to the Ministry of Health in managing applications for registration of human pharmaceutical products in Rwanda. It was compiled by the Technical Working Group (TWG) on Medicines Evaluation and Registration (MER) of the East African Community M... more

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Sharing simple facts. Useful information about menstrual health and hygiene

Government of India, Ministry of Rural Development, Dept. of Drinking water supply (2008) C1

This guidance booklet on Menstrual Hygiene Management (MHM) is intended for adolescent girls and young women. Issues associated with menstruation are never discussed openly and the silence surrounding menstruation burdens young girls by keeping them ignorant of this biological function. Even after t... more

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Women´s Mental Health: An evidence based review

WHO WHO (2000) C_WHO

This document adopts a health determinants framework for examining the evidence related to women’s poor mental health. From this perspective, public policy including economic policy, socio-cultural and environmental factors, community and social support, stressors and life events, personal behavio... more

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COVID-19 Vaccination, Country Readiness and Delivery: Supply and Logistics Guidance
recommended

World Health Organization WHO; UNICEF (2020) C_WHO

Working Document Nov. 2020 The COVAX Supply and Logistics workstream lead by UNICEF, Gavi and WHO have released a working copy of the COVID-19 Vaccination, Country Readiness & Delivery: Supply and Logistics Guidance. Countries might find this Guide useful when developing and strengthening their sup... more

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Global report on insecticide resistance in malaria vectors: 2010–2016

World Health Organization WHO (2018) C_WHO

As of October 2017, the global database comprised almost 30 000 records, including results from bioassays to measure phenotypic resistance, and biochemical and molecular tests for resistance mechanisms. The current report presents an overview of data on malaria vector resistance for 2010 to 2016. It... more

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Ebola checklist for pastors and other church leaders

United Methodist Church (2014)

A ‘checklist’, intended for Christian church leaders in West Africa, with relevant bible passages and advice regarding church practices and the education and support of communities.

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Pocket Book of Hospital Care For Maternal Emergencies Including Major Trauma and Neonatal Resuscitation

Maternal & Childhealth Advocacy International (MCAI) , Advanced Life Support Group (ALSG) Radcliffe (2015) C2

This pocket book is a 317 page summary of the emergency components of obstetrics and resuscitation of the newborn infant from our textbook "International Maternal & Childhealth Care - A practical manual for hospitals worldwide". The reader is referred to the textbook when more details on the medical... more

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A global brief on vector-borne diseases

World Health Organization (2014) C_WHO

With this World Health Day, WHO is drawing attention to a group of diseases that are spread by insects and other vectors, the heavy health and economic burdens they impose, and what needs to be done to reduce these burdens. Many of these diseases have been historically confined to distinct geographi... more

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Ebola virus disease in pregnancy: Screening and management of Ebola cases, contacts and survivors

World Health Organization (2015) C_WHO

Interim Guidance. This document provides guidance for: screening and triage of pregnant women in the context of an Ebola outbreak; infection prevention and control (IPC) precautions for pregnant women at risk of EVD transmission during childbirth and complication management; management of pregnant... more

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Consolidated guideline on sexual and reproductive health and rights of women living with HIV. Excecutive Summary

World Health Organization (WHO), Department of Reproductive Health and Research World Health Organization (WHO), Department of Reproductive Health and Research (2017) C_WHO

An integrated approach to health and human rights lies at the heart of ensuring the dignity and well-being of women living with HIV.

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Low-Threshold Psychosocial Support for Refugees and Asylum Seekers. A Project Guide
recommended

Zellmann, H. Médecins Sans Frontières (2018) C1

This guide is strongly practice -oriented and intended as an open resource when replicating similar methods of psychosocial care in other projects. It describes the steps in the development of our pilot project "Low threshold psychosocial support for refugees and asylum seekers’ in... more

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Alternative drinking-water disinfectants: Bromine, iodine and silver

World Health Organization (WHO) (2018) CC

Disinfection of drinking-water supplies has been one of the most significant public health advancements of the last century with respect to reducing waterborne disease.
Although chlorine has been used as the disinfectant of choice for public drinking-water supplies for the past century, a numbe... more

COVID-19 Vaccination, Country Readiness and Delivery: Supply and Logistics Guidance recommended

Low-Threshold Psychosocial Support for Refugees and Asylum Seekers. A Project Guide recommended

COVID-19 Vaccination, Country Readiness and Delivery: Supply and Logistics Guidance
recommended

Low-Threshold Psychosocial Support for Refugees and Asylum Seekers. A Project Guide
recommended