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Asthma traeatment in children: A pragmatic approach

Masekela, R.; Jeevanathrum, A.; Kling, S.; et al. South African Medical Journal (2018) CC

Asthma is a heterogeneous condition characterised by chronic inflammation and variable expiratory airflow limitation, with airway reversibility. Management of chronic inflammation with anti-asthma medication improves asthma control and quality of life. The aim of this journal is to provide an eviden... more

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European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years

Gaillard, E.A.; Kuehni, C.E.; Turner, S.; et al. European Respiratory Journal (2021) CC

Diagnosing asthma in children represents an important clinical challenge. There is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-diagnosis of asthma is frequent in children. A task force supported by the European Respiratory Society has developed these evidence... more

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The diagnosis of asthma in children: An evidence-based approach to a common clinical dilemma

Masekala, R.; Risenga, S.M.; Kitchin, O.P. et al. South African Medical Journal (2018) CC

Asthma is a heterogeneous condition characterised by chronic inflammation and variable expiratory airflow limitation, as well as airway reversibility. The diagnosis of asthma in young children is limited by the inability to perform objective lung function testing in this group of patients and the wi... more

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Summary of childhood asthma guidelines, 2021: A consensus document

Manjra, A.I.; van Niekerk, A.; White, D.A. et al. South African Medical Journal (2021) CC

Asthma is the most common chronic illness of childhood. The prevalence is rising and the mortality and morbidity from asthma are unacceptably high in South Africa. This article emphasizes the importance to make a correct diagnosis based, most importantly, on the clinical history and supported by inv... more

Guidelines for the management of chronic asthma in adolescents and adults

Lalloo, U.; Wong, M.; Abdool-Gaffar, S. et al. South African Family Practice (2007) CC

Asthma prevalence is increasing worldwide and surveys indicate that the majority of patients in developed and developing countries do not receive optimal care and are therefore not well controlled. The aim of these guidelines is to promote a better standard of treatment based on advances in the unde... more

Improving the global diagnosis and management of asthma in children

Lenney, W.; Bush, A.; Fitzgerald, D.A. et al. BMJ Journals (2018) CC

Asthma is the most common chronic condition in children worldwide. It affects daytime activities, sleep and school attendance and causes anxiety to parents, families and other carers. The quality of asthma diagnosis and management globally still needs substantial improvement. From infancy to the tee... more

The ‘jigsaw puzzle’ approach to building a diagnostic picture of asthma in primary care over time

Ryan, D.; Kocks, J.; Correia de Sousa, J. et al. International Primary Care Respiratory Group (2023) CC

Since there is no single objective diagnostic test for asthma this study suggests an approach of collecting and assembling pieces of clinical information to create a diagnostic picture, like making a jigsaw puzzle. These pieces should include demonstration of symptom and airway variability and/or br... more

Dolutegravir Resistance in Malawi’s National HIV Treatment Program

van Ossterhout, J. J.; Chipungu, C.; Nkhoma, L. et all. (2022) CC2

Dolutegravir HIV drug resistance (HIVDR) data from Africa remain sparse. We reviewed HIVDR results of Malawians on dolutegravir-based antiretroviral therapy (November 2020– September 2021). Of 6462 eligible clients, 33 samples were submitted to South Africa, 27 were sequenced successfully, and 8 ... more

Individual- and Facility-Level Factors Associated with Facility Testing among Men in Malawi: Findings from a Representative Community Survey

Balakasi, K.; Nichols, B. E.; Mphande, M.; et al. (2021) CC2

Men are underrepresented in HIV testing services throughout sub-Saharan Africa. HIV testing is critical to achieve the UNAIDS 95-95-95 goals, as it is the first entry point to HIV care. In Malawi, an estimated 14% of HIV positive men are undiagnosed, while only 6% of HIV positive women remain undiag... more

Provider-initiated HIV testing and TB screening in the era of universal coverage: Are the right people being reached? A cohort study in Blantyre, Malawi

Mair, L.; Corbett, E. L.; Feasey, H. R. A.; et al. PLOS One (2020) CC2

In a prospective cohort study in Bangwe primary care clinic, Blantyre, Malawi, all adults (18 years or older) presenting with an acute illness were screened for TB symptoms (cough, fever, night sweats, weight loss). Demographic characteristics were ... more

Integrated Family Planning and Immunization Service Delivery at Health Facility and Community Sites in Dowa and Ntchisi Districts of Malawi: A Mixed Methods Process Evaluation

Cooper, C. M.; Wille, J.; Shire, S.; et al. (2020) CC2

The Government of Malawi’s Health Sector Strategic Plan II highlights the importance of service integration; however, in practice, this has not been fully realized. We conducted a mixed methods evaluation of efforts to systematically implement integrated family planning and immunization services i... more

Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi

Prin, M.; Onofrey, L.; Purcell, L; et al. (2020) CC2

Most of the global burden of sepsis occurs in low- and middle-income countries (LMICs), but the prevalence and etiology of sepsis in LMICs are not well understood. In particular, the lack of laboratory infrastructure in many LMICs has historically precluded an assessment of the pathogens leading to ... more

Social capital insights from Healthy Settings needs assessment in Malawi

Rippon, S.; Beattie, T. K.; Lungu, K.; et al. (2018) CC2

Healthy Settings, a key component of Malawi’s Health Sector Strategic Plan (HSSP) 2011–2016, is the World Health Organization’s (WHO) holistic community-led approach to achieving health improvement by addressing social determinants of health, an approach which is central to the current WHO fra... more

A comprehensive review of cystic fibrosis in Africa and Asia

Abubakar, B.K.; Ahmad, U., Chau, D.M. et al. Saudi Journal of Biological Sciences (2023) CC

Cystic ﬁbrosis (CF) was earlier thought to be a disease prevalent in the West among Caucasians. However, quite a number of recent studies have uncovered CF cases outside of this region, and reported hundreds of unique and novel variant forms of CFTR. Here, we discuss the evidence of CF in parts of... more

Воспитание и забота о детях в условиях кризиса

Calam, R.; El-Khani, A. et al. United Nations Office on Drugs and Crime (UNODC) (2022) CC

Кризисные ситуации, такие как чрезвычайные происшествия, землетрясения и наводнения, участились и часто делают семьи очень уязвимыми. Родители, пережившие кризис�... more

Community health workers to improve uptake of maternal healthcare services: A clusterrandomized pragmatic trial in Dar es Salaam, Tanzania

Geldsetzer, P.; Mboggo, E.; Larson, E.; et al. (2019) CC2

PLoS Med 16(3): e1002768. https://doi.org/10.1371/journal.pmed.1002768 Home delivery and late and infrequent attendance at antenatal care (ANC) are responsible for substantial avoidable maternal and pediatric morbidity and mortality in sub-Saharan Africa. This cluster-randomized trial aimed to de... more

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Buruli Ulcer Disease: Buruli Oedema

Phillips, R.; S.Sarfo, E. Adu et. all Open Michigan (2011) CC

This video "Buruli Ulcer Disease: Buruli Odema" is part of a multimedia-based module by Richard Phillips, Stephen Sarfo, Emmanuel Adu, Veronica Owusu-Afriyie, and Cary Engleberg (University of Michigan). This video addresses the question of: What is the usual presentation and course of Buruli ulcer ... more

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Buruli Ulcer Disease: Buruli Plaque

Phillips, R.; S. Sarfo, E. Adu et. all Open Michigan (2011) CC

This video "Buruli Ulcer Disease: Buruli Plaque" is part of a multimedia-based module by Richard Phillips, Stephen Sarfo, Emmanuel Adu, Veronica Owusu-Afriyie, and Cary Engleberg (University of Michigan). This video addresses the question of: What is the usual presentation and course of Buruli ulcer... more

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Buruli Ulcer Disease: Cleaning and dressing the ulcer

Phillips, R.; S. Sarfo, E. Adu et. all Open Michigan (2011) CC

This video "Buruli Ulcer Disease: Cleaning and Dressing the Ulcer" is part of a multimedia-based module by Richard Phillips, Stephen Sarfo, Emmanuel Adu, Veronica Owusu-Afriyie, and Cary Engleberg (University of Michigan). This video addresses the question: How should Buruli ulcers be cleansed and d... more

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Effect of Artesunate–Amodiaquine on Mortality Related to Ebola Virus Disease

Etienne Gignoux, M.P.H., Andrew S. Azman, Ph.D., Martin de Smet, M.D., et al. (2016) C2

New England Journal of Medicine 374:1,pp23-32