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Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

Scherr, N.; R. Bieri, S.S. Thomas, et al. (2018) CC
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... more
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Two decades of public health achievements in lymphatic filariasis (2000–2020): reflections, progress and future challenges

M. Malecela; Gyapong, J.; Ramaiah, K. D.; et al. International Health (2021) C1
We are pleased to provide an editorial to introduce this series of articles on the achievements of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) over the last 2 decades. We are delighted that so many of the major players in this journey have agreed to contribute to this supplement,... more
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A scoping review of published literature on chikungunya virus

Mascarenhas, M.; S. GarasiaI, P. Berthiaume et al. (2018) CC
PLoS ONE 13(11): e0207554. https://doi.org/ 10.1371/journal.pone.020755
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Dengue diagnostics: serious inaccuracies are likely to occur if pre-analytical conditions are not strictly followed

Campos de Meli Iani, F.; A.C. Barbosa Caetano, J.C. Wenceslau Cocovich et al. (2021) CC
Mem Inst Oswaldo Cruz . 2021 Jan 29;115:e200287. doi: 10.1590/0074-02760200287. eCollection 2021. Sensitivity and negative predictive value were directly affected by sample storage conditions. RT-PCR and virus isolation showed greater dependence on well-conserved samples for an accurate diagnosis
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WHF IASC Roadmap on Chagas Disease

Echeverría, L.; Marcus, R.; Novick, G. et al. WHF Global Heart (2020) CC
The WHF IASC Roadmap proposes strategies and evidence-based solutions for healthcare professionals, health authorities and governments to help overcome the barriers to comprehensive care for Chagas disease patients. This roadmap describes an ideal patient care pathway, and explores the roadblocks ...ong the way, offering potential solutions based on avail­able research and examples in practice. It represents a call to action to decision-makers and health care professionals to step up efforts to eradicate Chagas disease. more
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The Chagas disease study landscape

Maguire, B.; Dahal, P.; Rashan, S. et al. PLoS Neglected Tropical Diseases (2021) CC
A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data platform. Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations s... more
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“We know about schistosomiasis but we know nothing about FGS”

Mazigo, H.; Sanson, A.; Lambert, V.; et al. (2021) CC
A qualitative assessment of knowledge gaps about female genital schistosomiasis among communities living in Schistosoma haematobium endemic districts of Zanzibar and Northwestern Tanzania. PloS Neglected Tropical Diseases September 30, 2021 https://doi.org/10.1371/journal.pntd.0009789 Schistosoma... more
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Prevalence of Common Diseases in Indigenous People in Colombia

Bauer, H.; Mendoza, G.; Kreienbrock, L. et al. National Library of Medicine (2022) CC
The Indigenous tribe called the Wiwa lives retracted in the Sierra Nevada de Santa Marta, Colombia. Little is known about their health status and whether the health care system in place covers their needs.
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Molecular and Clinical Aspects of Chronic Manifestations in Chagas Disease: A State-of-the-Art Review

Medina-Rincón, G.; Gallo-Bernal, S.; Jiménez, P.; et al. (2021) CC
Pathogens . 2021 Nov 16;10(11):1493.doi: 10.3390/pathogens10111493 .Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful... more
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Increasing access to comprehensive care for Chagas disease: development of a patient-centered model in Colombia

Marchiol, A; Forsyth, C.; Bernal, O.; et al. Pan American Health Organization PAHO (2017) C_WHO
Rev. Panam Salud Publica. 2017;41:e153. doi: 10.26633/RPSP.2017.153 Worldwide, over 6 million people are infected with Trypanosoma cruzi, the pathogen that causes Chagas disease (CD). In the Americas, CD creates the greatest burden in disability-adjusted life years of any parasitic infection. In Co... more
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Improving access to testing for Chagas disease in Colombia

Caicedo Díaz, RA,; Forsyth, C.; Bernal, OA; et al. Drugs for Neglected Diseases initiative DNDi (2019) CC
This is a summary of the following peer-reviewed, scientific article: Comparative Evaluation of Immunoassays to Improve Access to Diagnosis for Chagas Disease in Colombia.
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Diagnosis and Prevalence of Chagas Disease in an Indigenous Population of Colombia

Kann, S.; Dib, J.; Aristizabal, A.; et al. Multidisciplinary Digital Publishing Institute (2022) CC
Microorganisms . 2022 Jul 14;10(7):1427. Chagas disease (CD) is endemic in about 21 countries of the Americas. The disease has spread to recently Chagas-free regions, mainly due to migration, and can now also be diagnosed in countries such as the U... more
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Diagnosis and Clinical Management of Chagas Disease
recommended

Suárez, C.; Nolder, D.; García-Mingo, A.; et al. (2022) CC
Research and Reports in Tropical Medicine 2022:13 25–40 Chagas disease (CD) or American trypanosomiasis is a neglected parasitic disease associated with significant mortality and morbidity that includes long-term disability, social stigma and a mental health toll. Perceived as a disease of the ve... more
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“Chagas Express XXI”: Anew ArtScience social technology for health and science education

Araujo-Jorge, T.; Ferreia, R.; Rocha, R. et al. PLoS Neglected Tropical diseases (2021) CC
Chagas Disease (CD) affects 6–7 million people worldwide and isrelated topoverty-promo ting conditions. Chronic asymptomatic cases are mostly invisible tohealth systems. Aiming totranslate CD discoveries into education/information practices toraise al... more
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Chagas Disease: From Discovery to a Worldwide Health Problem Infectious Diseases

Freitas Lidani, K.; Antunes Andrade, F.; Bavia, L.; et. al. Frontiers Public Health (2019) CC
Front. Public Health, 02 July 2019 Sec. Infectious Diseases: Epidemiology and Prevention Volume 7 - 2019 | https://doi.org/10.3389/fpubh.2019.00166 Chagas disease (CD) is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi, that affects about 6–8 million people worldwide (1) a... more
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Chagas Disease: Detection of Trypanosoma cruzi by a New, High-Specific Real Time PCR

Kann, S.; Kunz, M.; Hansen, J.; et al. (2020) CC
J Clin Med . 2020 May 18;9(5):1517. doi: 10.3390/jcm9051517. Chagas disease (CD) is a major burden in Latin America, expanding also to non-endemic countries. A gold standard to detect the CD causing pathogen Trypanosoma cruzi is currently not avai... more
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A four-step process for building sustainable access to diagnosis and treatment of Chagas disease

Batista, C.; Forsyth, C.; Herazo, F.; et al. Pan American Journal of Public Health (2019) CC
Over 6 million people worldwide are infected with Trypanosoma cruzi, the protozoan that causes Chagas disease (CD). T. cruzi is transmitted by triatomine insects, congenitally, through uncontrolled blood donations and organ transplants, and via consumption of food or drink contaminated by triatomi... more
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Discrete typing units of Trypanosoma cruzi: Geographical and biological distribution in the Americas

Veláquez-Ortiz, N.; Herrera, G.; Hernández, C. et al. Scientific Data (2022) CC
Chagas disease caused by Trypanosoma cruzi is a public health issue in Latin America. This highly diverse parasite is divided into at least seven discrete typing units (DTUs) TcI-TcVI and Tcbat. Some DTUs have been associated with geographical distribution in epidemiological scenarios and clinical m... more
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The multidimensional comprehension of Chagas disease

Sanmatino, M.; Forsyth, C.; Avaria, A. et al. (2022) C2
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 117: e200460, 2022 Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness... more
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Health beliefs and health seeking behavior towards lymphatic filariasis morbidity management and disability prevention services in Luangwa District, Zambia: Community and provider perspectives

Maritim, P., A. Silumbwe, J.M. Zulu, et al. (2021) C2
Lymphatic filariasis (LF) infection if untreated results in fluid accumulation in the limbs or breasts (lymphedema) or genitalia (hydrocele) that is painful and causes great discomfort. Morbidity management and disability prevention (MMDP) strategies such as surgery for hydrocele, treatment of acute... more