Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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Buruli ulcer (BU) is a bacterial skin infection that is caused by Mycobacterium ulcerans and mainly affects people who reside in the rural areas of Africa and in suburban and beach resort communities in Australia.
Strengthening health-system emergency preparedness.
PLoS ONE 9(1): e87262. doi:10.1371/journal.pone.0087262
The WHO Training Resource on Primary Ear and Hearing Care is a new set of four training manuals aimed at equipping primary health care workers in
developing countries with simple and effective methods to reduce the burden of ear and hearing disorders.
No publication year indicated
In the context of the floods in August 2015 in Myanmar, the Disaster Risk Reduction Working Group (DRR WG) was requested to provide clear recommendations to the DMH (Department of Hydrology and Meteorology)to strengthen preparedness activities, in particular for t...he next Monsoon season. UNDP as the lead of the DRR WG’s Policy Technical Task force carried out a desk review on EW (Early Warning) from all the DRR WG’s members at national and community levels. The document synthesizes the received information related to baseline surveys, lessons learned from the 2015’s floods, studies, project documents and initial recommendations on EW. Those serve as a base to this analysis and its overall recommendations.
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A quick assessment sheet, which would allow to know the Social Accountability score of your medical school or medical students’ association. This assessment tool is part of the IFMSA/THEnet Students’ Toolkit on Social Accountability in Medical Schools. Find the full toolkit, the explanatory tabl...es, and a list of tools at www.ifmsa.org/social-accountability.
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WHO and UNITAID
in collaboration with IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials) network, PENTA (Paediatric European Network for Treatment of AIDS) foundation and experts from the Paediatric Antiretroviral Working Group
This manual is to assist health care providers and laboratory scientists to diagnose mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the clinical presentation and its diagnosis. The methods described are tailored to various levels of care and avail...able resources to improve the diagnosis and surveillance of the disease.
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This manual is addressed to health care providers dealing with Mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the disease, its clinical presentation and its surgical management. The manual is aimed particularly at district health care providers. A... comprehensive protocol, adapted to each form and stage of the disease, is presented together with comments on the levels of resources and capabilities necessary
to shorten the length of treatment, to prevent complications and to minimize undesired sequelae and thus to obtain the best possible outcome for each patient. Some sections include advice relevant to surgeons (e.g. relating to bone infection). However, the level to which particular comments are intended to apply should be clear from the context.
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This manual has been designed to be used in conjunction with two earlier WHO publications, "Basic tests for pharmaceutical substances" (1986) and "Basic tests for pharmaceutical dosage forms" (1991). Most of the pharmaceutical substances and dosage forms covered are included in the WHO Model List of... Essential Drugs. The present volume describes procedures for testing a further 23 pharmaceutical substances and 58 pharmaceutical dosage forms and also for testing 4 medicinal plant materials.
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To promote greater understanding of emergency preparedness, response and recovery, the UNESCO office in Kathmandu and Nepal’s Non Formal Education (NFE) Center of the Ministry of Education, have produced, “Education in Emergencies: Self-learning Materials for Non-Formal Education”. The textboo...ks intersperse interesting graphics with stories and poems to convey potentially life-saving lessons in education in emergenciesemer
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comment prévenir le choléra et les décès dans vos communautés. Ces diapositives et modules comprennent des informations sur les sujets suivants :
• Introduction et engagement de la communauté
• Ce qu’il faut savoir sur le choléra
• Les soins des personnes souffrant de diarrhée pen...dant une épidémie de choléra
• Le lavage des mains
• Les sels de réhydratation orale (SRO)
• Eau potable—Aquatabs®
• Eau potable—Dlo Lavi
• Eau potable—PuR®
• Stockage d’eau potable
• Préparation sécuritaire des aliments
• Assainissement et nettoyage sécuritaires
• Gestion des corps des victimes du choléra décédés chez eux
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