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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

Guidance note for practitioners leveraging climate-smart agriculture for peace: Insights from a bundle of interventions in Ghana

Alliance of Bioversity & CIAT; CGIAR (2024) CC

Climate change is one of the biggest crises of our time. Climate threats range from higher temperatures, heavy rainfalls and floods, erratic precipitation, droughts, desertification, and land degradation. This has negative implications on the quality and quantity of natural resources, such as land a... more

Preventing HIV misdiagnosis: implementation guide

World Health Organization WHO (2024) CC

HIV testing programmes need to ensure that all clients who test for HIV are provided with correct diagnoses. The accuracy of HIV testing is critical to prevent misdiagnosis, as the consequences of giving an incorrect test result can be serious for clients, HIV testing services, HIV programmes and pu... more

Antimicrobial Resistance Surveillance Guidance for the African Region

Africa Center for Disease Control and Prevention (2024) CC

Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren... more

Sanitation inspections User guide

World Health Organization WHO (2024) C_WHO

Safe sanitation is essential for health, from preventing infections to improving and maintaining mental and social well-being. Lack of adequate sanitation contributes to diarrhoeal diseases, parasitic infections, and undernutrition, as well as posing significant risks and causing anxiety, especial... more

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region
recommended

World Health Organization WHO (2024) C_WHO

The target audience of this document (and the associated online companion tool) includes WHO country offices in Member States of the African Region; Member States’ ministries of health and their public health emergency operation centres; relevant external assessment teams; and partners looking... more

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Pocket book of hospital care for children
recommended

World Health Organization (WHO) (2013) C_WHO

Guidelines for the Management of common childhood Illness. 2nd edition These guidelines focus on the management of the major causes of childhood mortality in most developing countries, such as newborn problems, pneumonia, diarrhoea, malaria, meningitis, septicaemia, measles and related conditions, ... more

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International and National Actions in Response to a Radiation Emergency

Wisner, B.; Adams, J World Health Organization WHO (2003) C_WHO

Annex of Environmental Health in Emergencies and Disaster; page 245 - 252 Information in Tables 1–4 summarizes the actions of the World Health Organization, the International Atomic Energy Authority, other international organizations, and local health authorities in response to a nuclear acci... more

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Essential Guide to Humanitarian Good Practice, 5th ed.
recommended

All in Diary (AID) (2016) C2

A practical tool for field based humanitarian workers. It provides up-to-date, clear and succint guidance on topics accross the humanitarian sector including references to current, relevant resources and practical tools.

External Link

Training Course on the Management of Severe Malnutrition Part 1: Introduction

WHO WHO (2002)

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Training Course on the Management of Severe Malnutrition Clinical Instructor Guide

WHO WHO (2002)

Download (952)

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Training Course on the Management of Severe Malnutrition Course Director Guide

WHO WHO (2002)

Download (998)

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Ensuring Food Safety In The Aftermath Of Natural Disasters

World Health Organization (2004)

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Paediatrics for Doctors in Papua New Guinea

Frank Shann and John Vince (2003)

A guide for doctors providing health services for children. 2nd edition

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Household Water Treatment and Storage

Oxfam (2008) C1

This technical brief presents the current options for safe storage and point of use water treatment. It is intended to help field staff working in a variety of locations to decide upon the most appropriate course of action for providing safe water for the communities in which they work. The effectiv... more

Communication for Behavioural Impact (COMBI)

UNIECF; WHO; FAO (2012)

A toolkit for behavioural and social communication in outbreak response

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National Guidelines for Tuberculosis Infection Control

National Tuberculosis Control Programme, Directorate General of Health Services, Ministry of Health and Family Welfare, Bangladesh (2011) C1

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Bench Aids for the diagnosis of filarial infections

World Health Organization WHO (1997) C_WHO

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Guidance for the Selection and Use of Personal Protective Equipment (PPE) in Healthcare Settings

Centers of Disease Control CDC (2014)

CDC has developed this slide set for use by staff development, infection control, and occupational health personnel for training healthcare personnel on how to select and use personal protective equipment PPE to protect themselves from exposure to microbiological hazards in the healthcare setting

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View PDF (1998)

WHO Interim Guidance for Ebola Event Management at Points of Entry

World Health Organization WHO (2014)

The aim is to provide early detection of potentially infected persons; to assist in implementing WHO recommendations related to Ebola management; and to prevent the international spread of the disease while allowing PoE authorities to avoid unnecessary restrictions and delays

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region recommended

Pocket book of hospital care for children recommended

Essential Guide to Humanitarian Good Practice, 5th ed. recommended

Essential and actionable measures for enhancing country preparedness for Viral Haemorrhagic Fever outbreaks in the WHO African Region
recommended

Pocket book of hospital care for children
recommended

Essential Guide to Humanitarian Good Practice, 5th ed.
recommended