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Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

Scherr, N.; R. Bieri, S.S. Thomas, et al. (2018) CC
Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite ... severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment. more
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The Use of Oral Cholera Vaccines for International Workers and Travelers to and from Cholera - Affected Countries

Global Task Force on Cholera Control (GTFCC) World Health Organisation (WHO) (2016) C_WHO
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Battling the Storm: Study on Cyclone Resistant Housing, 2nd ed.

Haq, Bashirul; Chattopadhayay-Dutt, Purnima Bangladesh Red Crescent Society , German Red Cross (2007) C1
The coastal regions of Bangladesh are hit by cyclones regularly. The country has evolved, in the face of repetitious calamities, a disaster prepare... more
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Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021–2030
recommended

World Health Organization WHO (2021) C_WHO
The road map sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups as well as cross-cutting targets aligned with the Sustainable Development G... more
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Trachoma The end in sight

International Coalition for Trachoma Control ICTC (2020) CC
Trachoma is an eye infection that for thousands of years caused many people to go blind across all continents. As the result of development and targeted interventions, trachoma is now limited to an estimated 57 countries, often affecting ... poorest populations of the world. Today, more than 2 million people are either blind or suffer from a very painful disability as the result of trachoma. more
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Blue Book. The Medical Guide for our Projects
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German Doctors German Doctors (2020) C2
9th edition; 4th English edition 2020
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Manual of the national tuberculosis and leprosy programme in Tanzania

Ministry of Health and Social Welfare, The United Republic of Tanzania (2006) C1
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Medical Anthropology Study of the Ebola Virus Disease (EVD) Outbreak in Liberia/West Africa

Omidian, P.; K. Tehoungue; J.Monger World Health Organization WHO (2014)
This study was carried out to better understand the local beliefs and practices likely to enhance or hinder efforts to respond to the Ebola Virus Disease outbreak in Liberia.
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Making a Difference the Global Ebola Response: Outlook 2015

UN Mission for Ebola Emergency Response (2015)
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Recovering from the Ebola Crisis: A summary report

UN Development Programme (2015)
In response to a call by the United Nations Secretary-General and the Governments of Guinea, Liberia and Sierra Leone, an international team conducted an Ebola Recovery Assessment.... aim was to contribute towards laying the foundation for short-, medium- and long-term recovery while the medical emergency response continues to tackle the epidemic. This summary report is based on a full report as well as three detailed reports submitted to each of the three governments as contributions to their national recovery planning processes. more
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Ebola: Beyond the health emergency. Executive Summary

Plan (2015)
Summary of research into the consequences of the Ebola outbreak for children and communities in Liberia and Sierra Leone
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Real Time Evaluation of the Ebola Control Programs in Guinea, Sierra Leone and Liberia. Final Report

International Federation of Red Cross And Red Crescent Societies (2015)
The scope includes the assessment of activities to improve the response to affected populations, stakeholders, partners and donors, building on les... more
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Exploring the impact of the Ebola outbreak on routine maternal health services

Jones, S.; C. Ameh Voluntary Service Overseas (2016) CC
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Zika, Dengue and Chikungunya Toolkit: Adaptation for Latin America and the Caribbean. Community Module

International Federation of Red Cross And Red Crescent Societies (2017) C1
The school and a community teaching modules are aimed at preventing vector-borne diseases through community participation. Meanwhile, the interactive toolkit is meant to be help raise awareness on h... more
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Namibia: National guidelines for the management of tuberculosis 2013-2017

Ministry of Health and Social Welfare (MOHSS) (2012) C2
Third Edition: Revised October 2012
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Temperature Check: Border Screening of Travelers Key to Stopping Ebola from Spreading

Golden, A. US Agency for International Development (2018) CC
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Strategic Response Plan for the Ebola Virus Disease Outbreak in the Provinces of North Kivu and Ituri, Democratic Republic of Congo (July-December 2019)
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Ministère de la Santé, DR Congo (2019) C1
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Diamonds - Stories of Women from the Asia Pacific Network of People Living with HIV

S. Paxton APN+; United Nations Development Fund for Women (2009) C2
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Strategic Response Plan for the measles emergency in the WHO European Region, September 2019–December 2020

World Health Organization WHO (2019) C_WHO
This Strategic Response Plan for the measles emergency in the WHO European Region (SRP) articulates the overall status of measles resurgence in ... WHO European Region and the priority actions needed to ensure an effective response to interrupt transmission, save lives and reverse the regional trend in case numbers. more
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Infection prevention and control for the care of patients with 2019-nCoV in healthcare settings

European Centre for Disease Prevention and Control ECDC (2020) C2
ECDC Technical Report, Fourth Update 3 July 2020