This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospita...ls in the Democratic Republic of the Congo between August 2005 and September 2009 to support the registration of pafuramidine for treatment of first stage HAT in collaboration with the United States Food and Drug Administration. Patients were treated with either 100 mg of pafuramidine orally twice a day for 10 days or 4 mg/kg pentamidine intramuscularly once daily for 7 days to assess the efficacy and safety of pafuramidine versus pentamidine. Pregnant and lactating women as well as adolescents were included.
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PLoS ONE 7(12): e52986. doi:10.1371/journal.pone.0052986. Opern Access please download from the website
The Journal of Infection in Developing Countries 7(3):289-292
Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause ...ght medbox">of pulmonary haemorrhage syndrome, the lack of global estimates for morbidity and mortality has contributed to its neglected disease status
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A new report by the world’s largest humanitarian network warns that the number of people needing humanitarian assistance every year as a result of climate-related disasters could double by 2050. I...t estimates that the number of people in need of humanitarian assistance as a result of storms, droughts and floods could climb beyond 200 million annually – compared to an estimated 108 million today.
It further suggests that this rising human toll would come with a huge financial price tag, with climate-related humanitarian costs ballooning
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Countdown to zero
2011- 2015
PLOS ONE | https://doi.org/10.1371/journal.pone.0192068 March 9, 2018
Vision 2030
Accessed: 17.11.2019
A 7.2-magnitude earthquake struck southwestern Haiti at 8:30am local time at a depth of around 10km. The epicentre was recorded around 12km northeast of SaintLouis-du-Sud, about 125km west ...ss="attribute-to-highlight medbox">of the capital Port-au-Prince.
● In the aftermath of the devastating 7.2-magnitude earthquake that hit Haiti on 14 August, authorities report more than 2,200 people dead, at least 344 missing, over 12,000 injured and upwards of 130,000 homes damaged or destroyed.
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This manual aims to provide practical guidance to field workers in order to maximise the nutritional impact of food security & livelihoods (FSL) interventions. This requires the systematic use of a ...‘nutrition lens’ at each step of the project cycle and a close collaboration between sectors.
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PLOS Neglected Tropical Diseases September 2014 | Volume 8 | Issue 9 | e3016 DOI: 10.1371/journal.pntd.0003016
PLOS ONE | https://doi.org/10.1371/journal.pone.0203986 October 3, 2018