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Standard Operating Procedure (SOP) : Waste management of used COVID-19 vaccines vials and ancillary supply
recommended

World Health Organization WHO, Regional Office of Africa (2021) C_WHO

The purpose of this Standard Operating Procedure (SOP) is to describe the detailed process on how to manage discarded COVID-19 vaccine vials and associated waste after COVID-19 vaccination activities end. The SOP provides clear instructions on how t... more

Heat-stability study of various insulin types in tropical temperature conditions: New insights towards improving diabetes care

Kaufmann, B.; Boulle, P.; Berthou, F.; et al. PLoS One (2021) CC

Strict storage recommendations for insulin are difficult to follow in hot tropical regions and even more challenging in conflict and humanitarian emergency settings, adding an extra burden to the management of people with diabetes. According to pharmacopeia unopened insulin ... must be stored in a refrigerator (2–8°C), while storage at ambient temperature (25–30°C) is usually permitted for the 4-week usage period during treatment. In the present work we address a critical question towards improving diabetes care in resource poor settings, namely whether insulin is stable and retains biological activity in tropical temperatures during a 4-week treatment period. To answer this question, temperature fluctuations were measured in Dagahaley refugee camp (Northern Kenya) using log tag recorders. Oscillating temperatures between 25 and 37°C were observed. Insulin heat stability was assessed under these specific temperatures which were precisely reproduced in the laboratory. Different commercialized formulations of insulin were quantified weekly by high performance liquid chromatography and the results showed perfect conformity to pharmacopeia guidelines, thus confirming stability over the assessment period (four weeks). Monitoring the 3D-structure of the tested insulin by circular dichroism confirmed that insulin monomer conformation did not undergo significant modifications. The measure of insulin efficiency on insulin receptor (IR) and Akt phosphorylation in hepatic cells indicated that insulin bioactivity of the samples stored at oscillating temperature during the usage period is identical to that of the samples maintained at 2–8°C. Taken together, these results indicate that insulin can be stored at such oscillating ambient temperatures for the usual four–week period of use. This enables the barrier of cold storage during use to be removed, thereby opening up the perspective for easier management of diabetes in humanitarian contexts and resource poor settings. more

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Interim recommendations for use of the Bharat Biotech BBV152 COVAXIN® vaccine against COVID-19

World Health Organization WHO (2022) C_WHO

These WHO interim recommendations for use of the BBV152 COVAXIN vaccine were developed on the basis of advice issued by the Strategic Advisory Group of Experts on Immunization (SAGE) and the evidence summary included in the background document and annexes referenced below. This document has been ... more

Mode Opératoire Normalisé (MON) : Gestion des déchets de flacons de vaccins anti-COVID-19 et de fournitures accessoires usagés
recommended

Organisation Mondiale de la Santé OMS (2021) C_WHO

L’objectif du présent Mode opératoire normalisé (MON) est de décrire le processus détaillé de gestion des flacons de vaccin anti-COVID-19 et des déchets associés jetés au terme d’activités de vaccination contre la COVID-19. Le mode opératoire normalisé fournit des instruc... more

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Quick Guide to Disposing Laboratory Waste

Ministry of Health. Environmental Health Department and Swaziland Health Laboratory Services (SHLS). The Goverment of the Kingdom of Swaziland (2015) C1

Accessed 3rd of October 2015

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Outbreak Response Forms

Polio Global Eradication Intiative (2010)

This collection of forms (in MS Excel) should be used in training and included in the outbreak response guidelines. The forms include tally sheets, check lists, household assessment and missed children forms. They can be adapted to specific national conditions.

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Determinants of damaged or poor quality supplies SOP

Ecumenical Pharmaceutical Network (EPN) (2011) C2

Last revised 2015. Original Word document on: http://www.epnetwork.org/Resources/Standard%20Operating%20Procedure/Determinants%20of%20damaged%20or%20poor%20quality%20supplies_SOP.doc

COVID-19 vaccine checklist
recommended

World Health Organization WHO (2021) C_WHO

1 March 2021 The COVID-19 vaccine checklist is for frontline health workers planning a COVID-19 vaccination session. This checklist can help them to prepare and complete a COVID-19 vaccination session at a fixed post or outreach session.

Job aid for COVID-19 vaccine administration: AZD1222 (‎ChAdOx1-S [‎recombinant]‎)‎ COVID-19 vaccine

World Health Organization WHO, Regional Office of Europe (2021) C_WHO

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Job aid for COVID-19 VACCINE administration - Pfizer–BioNTech COVID-19 vaccine, BNT162b2

World Health Organisation (WHO) (2021) C_WHO

updated version: 04/10/2021 Information about vaccine administration

Logistics flow and key questions – always consider also the implications on budgets, communication and human resource requirements including protocols, capacities and training needs
recommended

African Union; Africa CDC Centres for Disease Control and Prevention; World Health Organization WHO, et al. (2021) C1

“Guide to facilitate the implementation of the WHO/UNICEF “Guidance on developing a national deployment and vaccination plan for COVID-19 vaccines” for Africa